Using the Sinclair Method to Treat Alcohol Use Disorder

The Sinclair Method is an evidence-based approach to reducing alcohol consumption, centering on the use of naltrexone to block the rewarding effects of alcohol. Below is an overview of how it works, why it’s effective, and the research supporting its success.​

What Is the Sinclair Method?

• The Sinclair Method (TSM) involves taking naltrexone, an opioid receptor blocker, about one hour before drinking alcohol.​

• Unlike traditional models that require abstinence, TSM is designed for people who want to cut down their drinking but may not be ready to quit completely.​

• Naltrexone specifically blocks the “buzz” or pleasurable sensations associated with alcohol, reducing the urge to keep drinking.​

Why Does the Sinclair Method Work?

• Alcohol stimulates the release of endorphins, leading to feelings of pleasure and reinforcing the drinking behavior.​

• Naltrexone prevents endorphins from activating opioid receptors, “disconnecting” alcohol from the brain’s reward pathways.​

• This approach uses a behavioral principle called “extinction”—regular drinking combined with naltrexone weakens the link between alcohol and pleasure, ultimately reducing cravings.​

• Over time, many people experience a loss of desire to drink (“pharmacological extinction”), allowing for greater control and possibly complete abstinence.​

Research Supporting the Sinclair Method

• Multiple randomized controlled trials across countries have demonstrated the safety and efficacy of naltrexone as used in the Sinclair Method.​

• Clinical studies show naltrexone reliably reduces alcohol cravings and the urge for binge drinking, even among people who continue to drink socially.​

• Long-term results suggest that about 25% of people using this method may eventually stop drinking entirely, with others learning to drink moderately without old compulsive patterns.​

• The Sinclair Method has been recognized in academic literature, treatment guides, and addiction centers as a scientifically validated intervention for alcohol use disorder.​

Summary of Benefits

• Flexible, does not require immediate abstinence.​

• Gradual reduction in craving and consumption.​

• Improved quality of life, physical and mental health.​

• Backed by strong scientific research and real-world results.​

The Sinclair Method offers a practical, science-based solution for individuals struggling with problematic drinking, helping many change their habits and reclaim control over their lives.